Introduction: Patients with acute leukemia often experience symptoms of the disease itself and side effects of the treatment. Nurses play a major role in the interdisciplinary team that cares for these patients. Often it is the bedside nurse who recognizes the subtle changes that can lead to major complications. Fever, bruising, bleeding, infection, change in mental status, nausea, vomiting, and diarrhea are but a few of the problems patients with acute leukemia may develop. Differentiating disease-induced versus treatment-induced symptoms can be critical and requires a broad knowledge base, with an understanding of disease process, pharmacology, and symptom management. The complex nursing care of this population not only encompasses physical changes, but psychological as well and includes the patient and the patient’s identified support system.Main nursing problems:ThrombocytopeniaNeutrogenaAnemiaMucositisis/gastritisNausea/vomitingDiarrhea/constipationCNS alterationKnowledge deficitIneffective copingConclusion: It is projected that the incidence of acute leukemia will increase over the next few decades as the population of the United States ages. Age has been identified as a significant prognostic variable, and with more than 50% of acute myelogenous leukemia occurring in patients over the age of 60, clearly more research is needed. Great strides have been made in identifying genetic abnormalities associated with leukemia, and in developing novel therapies, with improvement in outcome data. Still, more research is needed. Ongoing and future clinical trials will study more novel therapies and new combinations of agents, as well as ways of minimizing graft versus host disease without compromising graft versus leukemia effect. Nurses must keep current of these trials and new agents to provide the essential patient care that is required.